Impacts from Government Regulations on the Canadian-U.S. Basis for Fed Cattle

Replaced with revised version of paper 09/01/09.Canada, Fed Cattle, Government Policy, International Trade, Prices, U.S., Livestock Production/Industries, Marketing, Q13, Q17, Q18,

Trade-Related Policy and Canadian-U.S. Fed Cattle Transactions Basis

Price differences among fed cattle prices in Canada and the United States (referred to here as fed cattle basis) are important for Canadian cattle feeders, but changing government regulations in Canada and the United States have made basis more variable. This article uses transaction data from Canadian feedlots to quantify fed cattle price differentials in light of new policy initiatives. Using transaction prices, we find that differing slaughter regulations, labeling laws, and policies affecting access to U.S. markets for Canadian cattle affect fed cattle basis.basis, Canada, cattle prices, government policy, international trade, market access, transaction prices, International Relations/Trade, Livestock Production/Industries,

Critical Factors Affecting Job Offers for New MIS Graduates

Due to the sharp IT budget cuts in corporate America, the slowing economy, and the offshore outsourcing trend, job opportunities for MIS graduates have become scarcer in recent years. In addition to having good academic performance, MIS students have adopted aggressive approaches, such as MIS internships, double majors, and more technical course work, to securing employment. However, research on the critical factors affecting MIS full-time job offers has not received enough attention, and little empirical research is currently available. This study intends to explore this important issue using a survey research methodology. 742 seniors majoring in MIS were surveyed in three different US universities and 213 seniors actually participated in the survey. The critical factors identified in this study include internship experience, the nature of internship experience, double majors, the time when students declare their MIS majors, grade point average, and gender difference. The research findings in this study indicate that student GPA, networking-oriented internship, and double majors are identified as the key items influencing MIS full time job offers

An Exploratory Case Study of the Benefits of Business Rules Management Systems

Business rules engines and business rule management systems (BRMS) are gaining popularity especially in large, complex, and real-time business environments. In essence, the business rules approach represents a new paradigm for compartmentalizing the formalization of business policies and rules as a separate component from application code. Given that this phenomenon has not yet been empirically investigated from a research perspective, we report on an exploratory case study undertaken to better understand the impacts of the business rules approach on activities throughout the software development lifecycle at a large Fortune 500 corporation. Our study integrates theoretical notions from the literature on knowledge reuse and systems theory with four constructs – centralization, standardization, externalization and structuration – to categorize the benefits arising from BRMS. Our results suggest that the application of the business rules approach has the potential to facilitate information systems development activities at all stages of the software development lifecycle

Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory

Alterations in cAMP signaling are thought to contribute to neurocognitive and neuropsychiatric disorders. Members of the cAMP-specific phosphodiesterase 4 (PDE4) family, which contains >25 different isoforms, play a key role in determining spatial cAMP degradation so as to orchestrate compartmentalized cAMP signaling in cells. Each isoform binds to a different set of protein complexes through its unique N-terminal domain, thereby leading to targeted degradation of cAMP in specific intracellular compartments. However, the functional role of specific compartmentalized PDE4 isoforms has not been examined in vivo. Here, we show that increasing protein levels of the PDE4A5 isoform in mouse hippocampal excitatory neurons impairs a long-lasting form of hippocampal synaptic plasticity and attenuates hippocampus-dependent long-term memories without affecting anxiety. In contrast, viral expression of a truncated version of PDE4A5, which lacks the unique N-terminal targeting domain, does not affect long-term memory. Further, overexpression of the PDE4A1 isoform, which targets a different subset of signalosomes, leaves memory undisturbed. Fluorescence resonance energy transfer sensor-based cAMP measurements reveal that the full-length PDE4A5, in contrast to the truncated form, hampers forskolin-mediated increases in neuronal cAMP levels. Our study indicates that the unique N-terminal localization domain of PDE4A5 is essential for the targeting of specific cAMP-dependent signaling underlying synaptic plasticity and memory. The development of compounds to disrupt the compartmentalization of individual PDE4 isoforms by targeting their unique N-terminal domains may provide a fruitful approach to prevent cognitive deficits in neuropsychiatric and neurocognitive disorders that are associated with alterations in cAMP signaling

Wide-Field Survey of Globular Clusters in M31. I. A Catalog of New Clusters

We present the result of a wide-field survey of globular clusters (GCs) in M31 covering a 3deg x 3deg field c. We have searched for GCs on CCD images taken with Washington CMT1 filters at the KPNO 0.9 m telescope using steps: (1) inspection of morphological parameters given by the SExtractor package such as stellarity, full maximum, and ellipticity; (2) consulting the spectral types and radial velocities obtained from spectra takena spectrograph at the WIYN 3.5 m telescope; and (3) visual inspection of the images of each object. We have and GC candidates, of which 605 are newly found GCs and GC candidates and 559 are previously known GCs. Amoects there are 113 genuine GCs, 258 probable GCs, and 234 possible GCs, according to our classification critee known objects there are 383 genuine GCs, 109 probable GCs, and 67 possible GCs. In total there are 496 genprobable GCs and 301 possible GCs. Most of these newly found GCs have T1 magnitudes of 17.5 - 19.5 mag, [17.9 < V < 19.9 mag assuming (C-T1) ~ 1.5], and (C-T1) colors in the range 1 - 2.Comment: accepted by AJ, using emulateapj.cl

ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation

Background: Delta Np63 alpha is an epithelial progenitor cell marker that maintains epidermal stem cell self-renewal capacity. Previous studies revealed that UV-damage induced p53 phosphorylation is confined to Delta Np63 alpha-positive cells in the basal layer of human epithelium. Results: We now report that phosphorylation of the p53 tumour suppressor is positively regulated by Delta Np63 alpha in immortalised human keratinocytes. Delta Np63 alpha depletion by RNAi reduces steady-state ATM mRNA and protein levels, and attenuates p53 Serine-15 phosphorylation. Conversely, ectopic expression of Delta Np63 alpha in p63-null tumour cells stimulates ATM transcription and p53 Serine-15 phosphorylation. We show that ATM is a direct Delta Np63 alpha transcriptional target and that the Delta Np63 alpha response element localizes to the ATM promoter CCAAT sequence. Structure-function analysis revealed that the Delta Np63-specific TA2 transactivation domain mediates ATM transcription in coordination with the DNA binding and SAM domains. Conclusions: Germline p63 point mutations are associated with a range of ectodermal developmental disorders, and targeted p63 deletion in the skin causes premature ageing. The Delta Np63 alpha-ATM-p53 damage-response pathway may therefore function in epithelial development, carcinogenesis and the ageing processes

Интернационализация подготовки научных кадров в развитых европейских странах:проблемы и уроки

Показаны формы международного сотрудничества в рамках интернационализации докторского образования, стратегии интернационализации высшего образования в целом и докторского в частности. Описан накопленный опыт, сформулированы основные уроки и полезные идеи, вытекающие из него.Показано форми міжнародного співробітництва у рамках інтернаціоналізації докторської освіти, стратегії інтернаціоналізації вищої освіти загалом та докторської зокрема. Описано накопичений досвід, сформульовано основні уроки та корисні ідеї, що випливають з нього.Forms of international cooperation in internationalization of doctoral education, strategies of internationalization in higher education in general and doctoral education in particular are shown. Experiences accumulated in this field are described; main lessons and useful ideas born from the experiences are outlined

Efficacy of recombinant Marek’s disease virus vectored vaccines with computationally optimized broadly reactive antigen (COBRA) hemagglutinin insert against genetically diverse H5 high pathogenicity avian influenza viruses

The genetic and antigenic drift associated with the high pathogenicity avian influenza (HPAI) viruses of Goose/Guangdong (Gs/GD) lineage and the emergence of vaccine-resistant field viruses underscores the need for a broadly protective H5 influenza A vaccine. Here, we tested experimental vector herpesvirus of turkey (vHVT)-H5 vaccines containing either wild-type clade 2.3.4.4A-derived H5 inserts or computationally optimized broadly reactive antigen (COBRA) inserts with challenge by homologous and genetically divergent H5 HPAI Gs/GD lineage viruses in chickens. Direct assessment of protection was confirmed for all the tested constructs, which provided clinical protection against the homologous and heterologous H5 HPAI Gs/GD challenge viruses and significantly decreased oropharyngeal shedding titers compared to the sham vaccine. The cross reactivity was assessed by hemagglutinin inhibition (HI) and focus reduction assay against a panel of phylogenetically and antigenically diverse H5 strains. The COBRA-derived H5 inserts elicited antibody responses against antigenically diverse strains, while the wild-type-derived H5 vaccines elicited protection mostly against close antigenically related clades 2.3.4.4A and 2.3.4.4D viruses. In conclusion, the HVT vector, a widely used replicating vaccine platform in poultry, with H5 insert provides clinical protection and significant reduction of viral shedding against homologous and heterologous challenge. In addition, the COBRA-derived inserts have the potential to be used against antigenically distinct co-circulating viruses and future drift variants.info:eu-repo/semantics/publishedVersio

Delays in diagnosis and bladder cancer mortality

BACKGROUND: Mortality from invasive bladder cancer is common, even with high-quality care. Thus, the best opportunities to improve outcomes may precede the diagnosis. Although screening currently is not recommended, better medical care of patients who are at risk (ie, those with hematuria) has the potential to improve outcomes. METHODS: The authors used the Surveillance, Epidemiology, and End Results-Medicare linked database for the years 1992 through 2002 to identify 29,740 patients who had hematuria in the year before a bladder cancer diagnosis and grouped them according to the interval between their first claim for hematuria and their bladder cancer diagnosis. Cox proportional hazards models were fitted to assess relations between these intervals and bladder cancer mortality, adjusting first for patient demographics and then for disease severity. Adjusted logistic models were used to estimate the patient's probability of receiving a major intervention. RESULTS: Patients (n = 2084) who had a delay of 9 months were more likely to die from bladder cancer compared with patients who were diagnosed within 3 months (adjusted hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.20-1.50). This risk was not markedly attenuated after adjusting for disease stage and tumor grade (adjusted HR, 1.29; 95% CI, 1.14-1.45). In fact, the effect was strongest among patients who had low-grade tumors (adjusted HR, 2.11; 95% CI, 1.69-2.64) and low-stage disease (ie, a tumor [T] classification of Ta or tumor in situ; adjusted HR, 2.02; 95% CI, 1.54-2.64). CONCLUSIONS: A delay in the diagnosis of bladder cancer increased the risk of death from disease independent of tumor grade and or disease stage. Understanding the mechanisms that underlie these delays may improve outcomes among patients with bladder cancer. Cancer 2010. © 2010 American Cancer Society.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78303/1/25310_ftp.pd